Neuroprotection: Rescue from Neuronal Death in the Brain

Free Radicals, Neuronal Death and Neuroprotection

Gangliosides rescue neuronal cells from death after trophic factor deprivation.

Serum-free cultures of PC 12 cells have been used as a model system for studying neuronal death occurring after neurotrophic factor deprivation. In this system, NGF rescues cells from death and prevents apoptotic DNA fragmentation. We report here that GM1 also promotes long-term survival of naive and NGF-pretreated PC 12 cells in serum-free medium and prevents internucleosomal cleavage of PC 12...

Deprenyl Can Mediate Neuronal Protection Rather than Neuronal Rescue

Background and Objective: Deprenyl is a drug for the treatment of Parkinson’s disease, where the dopaminergic neurons are the target of this drug. Several reports also documented that deprenyl has an effect on the sensory and motor neurons. There are some reports about the mode of action of deprenyl on m...

Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure

Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...

The study of brain death in Chaharmahal and Bakhtiari province in Iran from 2003 to 2013

Background and aims: There are different causes for brain death including head trauma, cerebrovascular accidents and intracranial space-occupying lesions. The present study was aimed to determine the causes of brain death in Chahar Mahal and Bakhtiari province due to high turnover of trauma in this area during 2003 to 2013...